Melatonin is primarily produced by the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin is affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the daytime hours and increase as night falls. Since it has important effects on circadian rhythms, melatonin has also been reported to have significant effects on reproduction in addition to sleep-wake cycles and antioxidant function.

Suggested Use:
1 tablet per day or as recommended by your health care professional.

Deficiency

Nighttime secretion of melatonin peaks between one to three years of age, and nocturnal levels naturally decline with age. Light inhibits melatonin secretion, so when the body is not exposed to an appropriate amount of environmental light, melatonin levels decrease. Low levels of melatonin in the body are often associated with occasional sleep disturbances that may impact overall health.

Sleep Support

Melatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency and awakening. In adults, studies have shown that doses between 0.3-75 mg have a positive effect on increasing total sleep time and reducing the time it takes to fall asleep.

Immune Support

Melatonin has been shown to be a powerful antioxidant and antioxidant inducer. It supports glutathione production and stimulates intracellular antioxidant enzyme production, including superoxide dismutase, glutathione peroxidase and glutathione reductase. It has also been found to scavenge free radicals and promote cytokine balance, which helps maintain normal inflammatory balance.