Melatonin is produced primarily in the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin is affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the day hours and increase when dark. Since it has important effects in affecting circadian rhythms, melatonin has been reported to have significant effects on sleep-wake cycles and antioxidant function.

Suggested Use:

1 or more tablets per day or as recommended by your health care professional.

Deficiency

Nighttime secretion of melatonin is at its highest during childhood and decreases over time. Research suggests that melatonin supplements support healthy sleep patterns in certain individuals, such as the elderly, individuals with nighttime working hours, or people traveling across time zones. Low levels of melatonin in the body are often associated with sleep disturbances.

Sleep Support

Melatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency and awakening.

Antioxidant Support

Melatonin has been shown to be a powerful antioxidant inducer. It supports glutathione production, and stimulates intracellular antioxidant enzyme production, including superoxide dismutase and glutathione peroxidase. It has also been found to scavenge free radicals and promote cytokine balance, which helps maintain normal inflammatory balance. Melatonin is also able to pass through the lipid part of low-density lipoprotein (LDL) and act as an antioxidant in cells. It has also been found to maintain healthy blood pressure levels.